New Nasal Covid-19 Vaccine Shows Promising Results in Hamster Studies
Scientists at the Max Delbruck Center for Molecular Medicine in Germany have made significant progress in developing a nasal vaccine against Covid-19. In experiments using hamsters, two doses of the weakened virus were found to block the replication of the virus in the upper airways, achieving "sterilizing immunity" and preventing illness.
The vaccine works by mimicking the natural infection process, with the weakened virus closely matching the original strain of the coronavirus. This approach is being touted as a promising method for inducing mucosal immunity, which is crucial for preventing respiratory infections like Covid-19.
In the hamster studies, the nasal vaccine performed better than two other vaccines in terms of immune response and ability to neutralize the virus. The researchers believe that this is because the live weakened vaccine closely mimics the natural infection process, allowing the body's immune system to mount a stronger response.
The German team is now eager to see the results of similar studies being conducted by another company, Codagenix, which is developing a nasal vaccine using a live but weakened virus. The company has completed phase II trials in South America and Africa, and the results are expected to be published later this year.
While the results from these studies are promising, experts caution that more testing needs to be done before any new Covid-19 vaccine can be widely released. The World Health Organization's vaccine tracker shows at least four nasal vaccines for Covid-19 in late-stage testing in people, and it is unclear how effective they will be.
The development of a Covid-19 vaccine has been slow, with progress being described as "slow and halting." However, researchers believe that this is because the challenges are significant, and the process of developing a new vaccine requires a great deal of time and resources.
In order to develop an effective vaccine against respiratory infections like Covid-19, it is necessary to induce mucosal immunity. This means boosting immune defenses in the tissues that line the upper airways, where the virus first enters the body.
Live attenuated viruses have been shown to be effective in inducing this type of immunity, but they can also pose risks for people with compromised immunity. As a result, researchers are working on developing new vaccines that use weakened or inactivated forms of the virus.
The success of these nasal vaccines will depend on their ability to induce strong mucosal immunity and prevent respiratory infections like Covid-19. While the results from the German team's studies are promising, more testing needs to be done before any new vaccine can be widely released.
Scientists at the Max Delbruck Center for Molecular Medicine in Germany have made significant progress in developing a nasal vaccine against Covid-19. In experiments using hamsters, two doses of the weakened virus were found to block the replication of the virus in the upper airways, achieving "sterilizing immunity" and preventing illness.
The vaccine works by mimicking the natural infection process, with the weakened virus closely matching the original strain of the coronavirus. This approach is being touted as a promising method for inducing mucosal immunity, which is crucial for preventing respiratory infections like Covid-19.
In the hamster studies, the nasal vaccine performed better than two other vaccines in terms of immune response and ability to neutralize the virus. The researchers believe that this is because the live weakened vaccine closely mimics the natural infection process, allowing the body's immune system to mount a stronger response.
The German team is now eager to see the results of similar studies being conducted by another company, Codagenix, which is developing a nasal vaccine using a live but weakened virus. The company has completed phase II trials in South America and Africa, and the results are expected to be published later this year.
While the results from these studies are promising, experts caution that more testing needs to be done before any new Covid-19 vaccine can be widely released. The World Health Organization's vaccine tracker shows at least four nasal vaccines for Covid-19 in late-stage testing in people, and it is unclear how effective they will be.
The development of a Covid-19 vaccine has been slow, with progress being described as "slow and halting." However, researchers believe that this is because the challenges are significant, and the process of developing a new vaccine requires a great deal of time and resources.
In order to develop an effective vaccine against respiratory infections like Covid-19, it is necessary to induce mucosal immunity. This means boosting immune defenses in the tissues that line the upper airways, where the virus first enters the body.
Live attenuated viruses have been shown to be effective in inducing this type of immunity, but they can also pose risks for people with compromised immunity. As a result, researchers are working on developing new vaccines that use weakened or inactivated forms of the virus.
The success of these nasal vaccines will depend on their ability to induce strong mucosal immunity and prevent respiratory infections like Covid-19. While the results from the German team's studies are promising, more testing needs to be done before any new vaccine can be widely released.
I'm thinking, maybe we don't need to develop so many different types of vaccines, just a few that actually work well? Like, why did it take so long for this nasal Covid-19 vaccine to come along? 
It's like they were searching in the dark for an answer. 
i mean its crazy that they were able to test it on hamsters first and now other companies are working on similar stuff codagenix is doing phase II trials in south america and africa which is like super exciting news 
I mean, it's not like a needle in the arm every time you need a booster shot, and it could actually prevent some of the worst symptoms of Covid-19 
The fact that it's showing promising results in hamster studies is like, a major breakthrough 
! I've been following the development of these vaccines for ages and I have to say, this one sounds super promising. The idea of inducing mucosal immunity is genius 
. We need something like this ASAP 
so we can finally get some relief from all this pandemic drama 
. Fingers crossed that it'll be ready soon and we can start seeing some real progress 
.
. I know some people might be skeptical about using a weakened virus, but from what I've read, it seems like this approach could be the key to inducing mucosal immunity 
. It's not always easy to create new vaccines, and it sounds like it's been a bit of a slow process 
. But if these nasal vaccines can deliver on their promise and prevent respiratory infections like Covid-19, I think we're onto something! 
I think it's a big deal that scientists found a nasal vaccine in hamster studies 
. Now, let's hope these results hold up when they do human trials 
and we can get a vaccine that actually works 
. It's crazy how much time has gone by since Covid-19 was first discovered, I feel like just yesterday we were all trying to figure out what was going on 
. Anyway, fingers crossed for these nasal vaccines! 
. I'm intrigued by the approach of using a live weakened virus to induce mucosal immunity, as it's a more natural way for our bodies to deal with respiratory infections. However, it's crucial that we don't get ahead of ourselves and assume that this will directly translate to human trials 
. The development of an effective vaccine against Covid-19 has been a long and challenging process, and there's still so much work to be done before we can say that we've found the holy grail 
the thing is, these vaccines use live weakened viruses which is a good idea because they can mimic the natural infection process and help our bodies build up immunity. but at the same time, there are concerns about people with compromised immune systems... 
what do you guys think - should we get excited about this new vaccine or wait for more results? 
. I mean, who wouldn't want to avoid getting sick again with a simple nose spray? 
.
! And I'm glad to see researchers taking a cautious approach, knowing that more testing is needed before any new vaccine can hit the market 
. Safety first, right? 
. It's been ages since we've seen some real progress in vaccination research. I mean, who doesn't love the idea of a shot that just goes up your nose? 
But seriously, inducing mucosal immunity is key to preventing respiratory infections, so if this thing works, it could be a game-changer.
. With so many nasal vaccines in late-stage testing, fingers crossed that one of them actually works as well as this one does.
. We'll just have to keep our fingers crossed until then... 
I mean, four nasal vaccines are already in late-stage testing, that's a lot of promising stuff 
It sounds like it's gonna work really well, especially since it mimics the natural infection process. I've been following all the developments on this one and I'm loving how it's coming along