Scientists in Germany claim to have developed a nasal vaccine that can effectively shut down Covid-19 infections at the very start of their journey into the body. In animal studies, two doses of this live but weakened form of the virus demonstrated "sterilizing immunity" and prevented illness, a highly sought-after outcome during the pandemic.
The vaccine was tested on hamsters, where it successfully blocked the virus from replicating in the upper airways. The researchers believe that this approach could be a game-changer in the fight against Covid-19, as it targets the mucosal immunity – the tissues lining the upper airways – where the virus initially enters the body.
This new vaccine takes an old approach to vaccination and has been updated for the modern era. Scientists have manipulated the genetic material of the virus to make it harder for cells to translate, essentially rendering it harmless while still allowing the immune system to recognize and fight it off.
The results are promising, with two doses of the nasal vaccine outperforming other vaccines tested in hamsters. The researchers also note that this approach can potentially provide a stronger and more long-lasting immunity than traditional shots, which reside primarily in the blood.
While caution is warranted, experts say that the results look encouraging and that further testing is needed before the vaccine can be widely used. At least four nasal vaccines for Covid-19 are currently undergoing late-stage testing in humans, according to the World Health Organization's vaccine tracker.
It's a promising development in the fight against Covid-19, but there are still challenges to overcome. The nasal vaccines in use in China and India rely on harmless adenoviruses to ferry their instructions into cells, and while they may be effective, their effectiveness data has not been published yet.
Other nasal vaccines are also being developed, including one that uses a live but weakened version of the virus, similar to the German vaccine. These studies will likely provide more insight into the potential of this approach against Covid-19.
The development of a pan-coronavirus vaccine that induces mucosal immunity and is long-lived has been hailed as a vital goal in the fight against Covid-19. With new vaccines on the horizon, scientists are cautiously optimistic about the prospects for this promising approach.
The vaccine was tested on hamsters, where it successfully blocked the virus from replicating in the upper airways. The researchers believe that this approach could be a game-changer in the fight against Covid-19, as it targets the mucosal immunity – the tissues lining the upper airways – where the virus initially enters the body.
This new vaccine takes an old approach to vaccination and has been updated for the modern era. Scientists have manipulated the genetic material of the virus to make it harder for cells to translate, essentially rendering it harmless while still allowing the immune system to recognize and fight it off.
The results are promising, with two doses of the nasal vaccine outperforming other vaccines tested in hamsters. The researchers also note that this approach can potentially provide a stronger and more long-lasting immunity than traditional shots, which reside primarily in the blood.
While caution is warranted, experts say that the results look encouraging and that further testing is needed before the vaccine can be widely used. At least four nasal vaccines for Covid-19 are currently undergoing late-stage testing in humans, according to the World Health Organization's vaccine tracker.
It's a promising development in the fight against Covid-19, but there are still challenges to overcome. The nasal vaccines in use in China and India rely on harmless adenoviruses to ferry their instructions into cells, and while they may be effective, their effectiveness data has not been published yet.
Other nasal vaccines are also being developed, including one that uses a live but weakened version of the virus, similar to the German vaccine. These studies will likely provide more insight into the potential of this approach against Covid-19.
The development of a pan-coronavirus vaccine that induces mucosal immunity and is long-lived has been hailed as a vital goal in the fight against Covid-19. With new vaccines on the horizon, scientists are cautiously optimistic about the prospects for this promising approach.
they developed a nasal vaccine that can literally stop covid from infecting u at the beginnin lol imagine bein able to avoid all that sickness & stuff! its like a game changer for sure. i mean, traditional vaccines dont work as good for mucosal immunity which is where u body first encounters virus so this new one takes an old approach but makes it modern lol. gotta try it out tho! only caution is more testing needed 4 sure 
, scientists in Germany are like "hold up, let's try something else" 
That's some next-level stuff right there! I'm loving the fact that they're targeting the mucosal immunity - that's where the virus usually crashes its party 
. And if this thing works, we might be looking at a stronger and more long-lasting immunity than traditional shots 
.
. It's like they're playing catch-up with the virus, but maybe that's exactly what we need 
. Fingers crossed these nasal vaccines can provide some real relief and take us to a more Covid-free future 
#NasalVaccine #Covid19 #MucosalImmunity #ScienceWins
they've basically created a vaccine that just sits there in your nose and goes "hey immune system I'm here" meanwhile the virus is like "uh no thanks" 
but seriously, if it works out and can provide long lasting immunity then we're golden 
. The idea of targeting mucosal immunity in the upper airways is genius – it makes total sense that we should be protecting our nose and sinuses first 
. The fact that this approach could provide stronger, longer-lasting immunity than traditional shots is a major win in my book 
. Of course, there's still more testing to do before it's widely available, but I'm definitely excited about the prospects for this new vaccine tech 
.
. no more constant shots or worrying about long-term effects 
. still, gotta be cautious with testing & rollout 
. can't have any major side effects or false promises 
. but if it works... 
And if it really does work as well as they say, that'd be a total game-changer. I mean, we're still dealing with this pandemic, but maybe one day we'll actually get to leave our masks on the shelf 
. And the fact that it targets the mucosal immunity makes sense, since that's where Covid-19 first enters our bodies. This could be the breakthrough we need to finally get rid of Covid-19 for good 
. I'm definitely keeping an eye on this one and hoping it becomes a reality soon 
.
...I mean, can you even imagine how much it would've saved my sister during her last bout with Covid? 
She was stuck in bed for like a week and had to miss her niece's birthday party...anyway, I digress 
...seriously though, if this thing works out, we'll be singing its praises from the rooftops 
. The fact that it can prevent illness at the start of infection is literally mind-blowing 
kinda like how we've been trying to adult with masks and hand sanitizer, now someone's got a 'vaccine' that's like "hey, I'll just chill at the entrance" 
meanwhile, china and india are still over here like "we good, our adenoviruses work too, no big deal" 
.